To identify the aetiology of CA-ARTI in a subset of participants in the WP4 trial, and to perform laboratory validations of the pathogen and host-based CA-ARTI-Dx evaluated in WP4, using samples obtained in the trial.
To provide comprehensive data on the laboratory-based validations (detection of pathogen, host biomarker, and AMR) of the CA-ARTI-Dx being evaluated on a regular basis in order to ‘machine-learn’ the clinical algorithms developed in WP1.
To screen for host biomarkers in an initial subset of blood/serum samples collected in WP4, and then validate these on the subsequent blood/serum samples from WP4.
To understand and quantify the burden of AMR, in a subset of nasal, pharyngeal and gastrointestinal samples, with respect to the type, days and doses of antibiotics prescribed based on the following outcomes: i) development or amplification of the AMR burden in the “normal” respiratory and intestinal flora after completion of antibiotic therapy, and ii) selection of pathogens with a resistant phenotype post therapy. These data will allow estimation of the cost of AMR and will feed into WP5.
To develop and support a biobank of well-characterized samples (including blood/serum and other relevant samples to be defined) and bacterial strains isolated from CA-ARTI patients.
https://www.value-dx.eu/wp-content/uploads/2019/07/Logo-300x124.png00melanie.hostehttps://www.value-dx.eu/wp-content/uploads/2019/07/Logo-300x124.pngmelanie.hoste2019-09-29 10:13:222020-09-21 13:37:54WP Co-Lead Face-to-Face & Business Plan Meeting
University of Antwerp, bioMérieux, and Wellcome Trust
to coordinate VALUE-Dx, a European Public-Private Partnership
to fight antimicrobial resistance through diagnostics
https://www.value-dx.eu/wp-content/uploads/2019/09/VALUE-Dx_logo_white4.png4281226melanie.hostehttps://www.value-dx.eu/wp-content/uploads/2019/07/Logo-300x124.pngmelanie.hoste2019-09-26 14:38:492020-09-21 13:38:16Launch of VALUE-Dx