{"id":3756,"date":"2022-07-12T12:30:24","date_gmt":"2022-07-12T12:30:24","guid":{"rendered":"https:\/\/www.value-dx.eu\/?p=3756"},"modified":"2022-07-14T07:38:21","modified_gmt":"2022-07-14T07:38:21","slug":"poc-diagnostics-in-general-practice-the-effects-on-antimicrobial-resistance","status":"publish","type":"post","link":"https:\/\/www.value-dx.eu\/index.php\/2022\/07\/12\/poc-diagnostics-in-general-practice-the-effects-on-antimicrobial-resistance\/","title":{"rendered":"POC Diagnostics in General Practice: the Effects on Antimicrobial Resistance"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jzkylawd-ba86e75d702405f62001a756eb35483d\">\n.avia-section.av-jzkylawd-ba86e75d702405f62001a756eb35483d{\nbackground-color:#08b4a0;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-jzkylawd-ba86e75d702405f62001a756eb35483d main_color avia-section-default avia-no-border-styling  avia-builder-el-0  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el_before_av_codeblock  avia-builder-el-first  av-linked-heading'><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >POC Diagnostics in General Practice: the Effects on Antimicrobial Resistance<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1cjng-9db903d36b325f87b66fb9ba7e96614e\">\n.avia-section.av-1cjng-9db903d36b325f87b66fb9ba7e96614e{\nbackground-color:#1b7ca4;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-1cjng-9db903d36b325f87b66fb9ba7e96614e main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-3756'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0\">\n.flex_column.av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0{\nborder-radius:0px 0px 0px 0px;\npadding:50px 5% 50px 5%;\n}\n<\/style>\n<div  class='flex_column av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0 av_one_full  avia-builder-el-4  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div  '     ><p><section  class='av_textblock_section av-l5kpy3ab-b585287b154436a262512fdda9d589f6 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span style=\"font-weight: 400;\"><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-3757 alignleft\" src=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-300x196.jpg\" alt=\"\" width=\"338\" height=\"221\" srcset=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-300x196.jpg 300w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-1030x671.jpg 1030w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-768x501.jpg 768w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-1536x1001.jpg 1536w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-1500x978.jpg 1500w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image-705x460.jpg 705w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2022\/07\/VALUE-Dx-publication-image.jpg 1657w\" sizes=\"(max-width: 338px) 100vw, 338px\" \/>In June 2022, VALUE-Dx contributed to a new publication titled \u2018<\/span><i><span style=\"font-weight: 400;\">The Opportunity of Point-of-Care Diagnostics in General Practice: Modelling the Effects on Antimicrobial Resistance<\/span><\/i><span style=\"font-weight: 400;\">\u2019, that appeared in the open-access journal PharmacoEconomics. The aim of the study was to quantify the investments required for a large-scale rollout of point-of-care (POC) diagnostic testing in Dutch primary care, as well as the impact on antimicrobial resistance (AMR) due to reduced use of antibiotics.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">AMR is a public health threat that is mainly caused by unnecessary use of antibiotics. Community-acquired acute respiratory tract infections (CA-ARTIs) are a major driver of antibiotic consumption in primary care. It is estimated that each year more than 650.000 infections and 30.000 attributable deaths in Europe or 1.27 million deaths worldwide are caused by resistant organisms.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">An individual-based model was developed to simulate CA-ARTI consultations at Dutch GP practices. It compared a scenario where GPs test all CA-ARTI patients with a hypothetical diagnostic strategy to a scenario where the current standard-of-care is continued for the years 2020-2030. Differences in costs and future AMR rates were estimated.\u00a0<\/span><\/p>\n<p><b>Results of the study<\/b><\/p>\n<p><span style=\"font-weight: 400;\">The results show that improved diagnostics may reduce AMR in the next decade, but that there also are major costs associated. When comparing the current standard-of-care to the diagnostic algorithm, the latter increases the total costs of GP consultations for CA-ARTI by 9% and 19%, when priced at \u20ac5 and \u20ac10. The hypothetical diagnostic strategy can partly restrain the forecast increase in Streptococcus pneumoniae resistance against penicillins from 3.8 to 3.5% in 2023, albeit with considerable uncertainty.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/span><\/p>\n<p><b>Conclusions<\/b><\/p>\n<p><span style=\"font-weight: 400;\">The results show that the costs of consultations increase, while antibiotic consumption and AMR decrease when implementing a hypothetical diagnostic strategy for all CA-ARTI patients in primary care. Interventions with limited gains for individual patients, but considerable potential related to antibiotic consumption and AMR, can require novel health-economic methods to assess and communicate the potential benefits related to AMR.\u00a0\u00a0\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">You can read<\/span><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s40273-022-01165-3\" target=\"_blank\" rel=\"noopener\"> <span style=\"font-weight: 400;\">the publication here<\/span><\/a><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-yfjs-fd93b228aa1b13a89db4cc3964440224 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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