{"id":2534,"date":"2020-06-26T11:31:31","date_gmt":"2020-06-26T11:31:31","guid":{"rendered":"https:\/\/hosting.uantwerpen.be\/valuedx\/?p=2534"},"modified":"2020-09-21T13:30:39","modified_gmt":"2020-09-21T13:30:39","slug":"evaluating-the-clinical-and-cost-effectiveness-of-ca-arti-diagnostics-through-prudence-trial","status":"publish","type":"post","link":"https:\/\/www.value-dx.eu\/index.php\/2020\/06\/26\/evaluating-the-clinical-and-cost-effectiveness-of-ca-arti-diagnostics-through-prudence-trial\/","title":{"rendered":"Evaluating the clinical and cost-effectiveness of CA-ARTI diagnostics through PRUDENCE trial"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jzkylawd-ba86e75d702405f62001a756eb35483d\">\n.avia-section.av-jzkylawd-ba86e75d702405f62001a756eb35483d{\nbackground-color:#08b4a0;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-jzkylawd-ba86e75d702405f62001a756eb35483d main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-parallax container_wrap fullsize'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-2534'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kbw4ue5u-71c36b29d2f541f8f28f51ad086b9a6a\">\n#top .av-special-heading.av-kbw4ue5u-71c36b29d2f541f8f28f51ad086b9a6a{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kbw4ue5u-71c36b29d2f541f8f28f51ad086b9a6a .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kbw4ue5u-71c36b29d2f541f8f28f51ad086b9a6a .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kbw4ue5u-71c36b29d2f541f8f28f51ad086b9a6a av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-1  el_before_av_codeblock  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Evaluating the clinical and cost-effectiveness of CA-ARTI diagnostics through PRUDENCE trial<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1cjng-9db903d36b325f87b66fb9ba7e96614e\">\n.avia-section.av-1cjng-9db903d36b325f87b66fb9ba7e96614e{\nbackground-color:#1b7ca4;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-1cjng-9db903d36b325f87b66fb9ba7e96614e main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-2534'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0\">\n.flex_column.av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0{\nborder-radius:0px 0px 0px 0px;\npadding:50px 5% 50px 5%;\n}\n<\/style>\n<div  class='flex_column av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0 av_one_full  avia-builder-el-4  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div  '     ><section  class='av_textblock_section av-yfjs-a24130328363a5d48e40d9c86a7bb2c6 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-106 alignleft\" src=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-300x200.jpg\" alt=\"\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-300x200.jpg 300w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-768x513.jpg 768w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-1030x688.jpg 1030w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-1500x1001.jpg 1500w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-705x471.jpg 705w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2019\/07\/shutterstock_588432440-450x300.jpg 450w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/>The invention of antimicrobials was a major breakthrough in medical science that saved millions of lives. Antimicrobials are used to treat illness caused by bacteria. Development of these medicines meant that illnesses, like pneumonia, which were once often fatal, could now usually be successfully treated. But effectiveness of antimicrobials is now decreasing because they are being overused.<\/p>\n<p>Microorganisms that are being exposed to antimicrobials change genetically over time, making it harder for the antimicrobials to work against them. As a result, \u201csuperbugs\u201d are developing. We have no effective treatment for some of these \u201csuperbugs\u201d. The development of resistance to antimicrobials is a major public health concern worldwide. Unhelpful, clinically unwarranted variation in care is a major contributor. Point-of-care testing that is proven to be cost-effective in clinical trials could help improve the quality of care and thus patient outcomes. This is especially true for community-acquired acute respiratory tract infections (CA-ARTI), the most common acute reasons for consulting health services in community care setting and for antimicrobial use.<\/p>\n<p>The aim of <strong><em>Platform Randomised controlled trial of point of care Diagnostics for Enhancing the quality of aNtibiotic prescribing for Community acquired acute respiratory tract infection (CA-ARTI) in ambulatory care in Europe (PRUDENCE)<\/em><\/strong> is to determine if having a CA-ARTI diagnostic (CA-ARTI-Dx) test result available when a clinician is considering, or plans to prescribe an antimicrobial, leads to more appropriate prescribing decisions, without causing harm to patients. PRUDENCE is a multi-country, prospective, individually randomised, platform clinical trial in community care with a nested process evaluation. The trial is a diagnostic strategy intervention study to evaluate the use of clinical algorithms that include a CA-ARTI-Dx, compared to usual clinical care without CA-ARTI-Dx.<\/p>\n<p>The PRUDENCE trial is managed by the University of Oxford, University Medical Centre Utrecht, Abbott and BD, and it will involve up to 10 primary care networks in Europe. Designed as a flexible platform trial, it has the capability of including additional interventions without having to start a new trial each time a new intervention emerges. It will also involve a mixed-methods process evaluation to capture data to understand how point-of-care tests are used and viewed by clinicians and patients to inform recommendations on implementation.<\/p>\n<p>Read the main objectives of PRUDENCE <a href=\"https:\/\/www.value-dx.eu\/index.php\/work-package-4\/\">here<\/a>.<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3b8mw-b506a38e8d00a7f4906eea669cebc6be\">\n.flex_column.av-3b8mw-b506a38e8d00a7f4906eea669cebc6be{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-3b8mw-b506a38e8d00a7f4906eea669cebc6be av_one_fifth  avia-builder-el-6  el_after_av_one_full  el_before_av_one_fifth  first flex_column_div av-zero-column-padding  column-top-margin'     ><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" 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