{"id":2508,"date":"2020-06-18T13:37:11","date_gmt":"2020-06-18T13:37:11","guid":{"rendered":"https:\/\/hosting.uantwerpen.be\/valuedx\/?p=2508"},"modified":"2020-09-21T13:31:14","modified_gmt":"2020-09-21T13:31:14","slug":"wp1-review-and-analysis-of-diagnostic-test-accuracy-for-ca-arti","status":"publish","type":"post","link":"https:\/\/www.value-dx.eu\/index.php\/2020\/06\/18\/wp1-review-and-analysis-of-diagnostic-test-accuracy-for-ca-arti\/","title":{"rendered":"Review and analysis of diagnostic test accuracy for CA-ARTI"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-jzkylawd-ba86e75d702405f62001a756eb35483d\">\n.avia-section.av-jzkylawd-ba86e75d702405f62001a756eb35483d{\nbackground-color:#08b4a0;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-jzkylawd-ba86e75d702405f62001a756eb35483d main_color avia-section-default avia-no-border-styling  avia-builder-el-0  el_before_av_section  avia-builder-el-first  avia-bg-style-parallax container_wrap fullsize'  ><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-2508'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kc36fi2p-3643143dbbc61fcfe2721a8339e09f3e\">\n#top .av-special-heading.av-kc36fi2p-3643143dbbc61fcfe2721a8339e09f3e{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kc36fi2p-3643143dbbc61fcfe2721a8339e09f3e .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kc36fi2p-3643143dbbc61fcfe2721a8339e09f3e .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kc36fi2p-3643143dbbc61fcfe2721a8339e09f3e av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-1  el_before_av_codeblock  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Review and analysis of diagnostic test accuracy for CA-ARTI <\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n\n\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1cjng-9db903d36b325f87b66fb9ba7e96614e\">\n.avia-section.av-1cjng-9db903d36b325f87b66fb9ba7e96614e{\nbackground-color:#1b7ca4;\nbackground-image:unset;\n}\n<\/style>\n<div id='av_section_2'  class='avia-section av-1cjng-9db903d36b325f87b66fb9ba7e96614e main_color avia-section-default avia-no-border-styling  avia-builder-el-3  el_after_av_section  el_before_av_section  avia-bg-style-scroll container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-2508'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0\">\n.flex_column.av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0{\nborder-radius:0px 0px 0px 0px;\npadding:50px 5% 50px 5%;\n}\n<\/style>\n<div  class='flex_column av-k0i4yzrj-318dd765ad6f41d2fe86b741f8548ed0 av_one_full  avia-builder-el-4  el_before_av_one_fifth  avia-builder-el-first  first flex_column_div  '     ><section  class='av_textblock_section av-yfjs-a24130328363a5d48e40d9c86a7bb2c6 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p><img fetchpriority=\"high\" decoding=\"async\" class=\" wp-image-2510 alignleft\" src=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-300x157.jpeg\" alt=\"\" width=\"332\" height=\"174\" srcset=\"https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-300x157.jpeg 300w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-768x403.jpeg 768w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-1030x540.jpeg 1030w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-1500x787.jpeg 1500w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-710x375.jpeg 710w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-705x370.jpeg 705w, https:\/\/www.value-dx.eu\/wp-content\/uploads\/2020\/06\/Researcher-with-microscope-450x236.jpeg 450w\" sizes=\"(max-width: 332px) 100vw, 332px\" \/>VALUE-Dx is working on identifying the optimal tests that can diagnose reliably all patients with specific Community-Acquired Acute Respiratory Tract Infections (CA-ARTIs). WP1 conducted a systematic review and meta-analysis of point-of-care diagnostic test accuracy (DTA) for CA-ARTI including Rapid Antigen Detection Technique (RADTs), Nucleic acids amplification tests, imaging techniques, signs and symptoms, and host biomarkers. The performance of several pathogen-based RADTs to define the aetiology of CA-ARTI was investigated. Influenza virus, Respiratory Syncytial virus (RSV) and group <em>A Streptococcus<\/em> (GAS) RADTs showed a good DTA with an AUC &gt;80%. Sensitivity and specificity differed depending on patient population (children and adults), brand name and test type; in particular, immunochromatographic assays were the most represented with a high DTA (AUC &gt;87%). No significant heterogeneity rises for subgroup analysis by type of setting (community care, ED, LCTF). PCR tests proved very useful to exclude the diagnosis of CA-ARTIs with a very good sensitivity (80-98%) and high specificity (94-99%) and to reduce inappropriate antibiotic usage. Lung ultrasound showed also excellent diagnostic efficiency tool for the diagnosis of bacterial CAP (AUC 94%).<\/p>\n<p>In addition, WP1 is involved in developing a roadmap to provide recommendations for future development, implementation, and increased uptake of CA-ARTI diagnostics. The roadmap will address short-term and long-term goals and aims to provide key information to help diagnostic innovators and funders prioritize investment decisions. To improve antibiotic use in CA-ARTI by diagnostics, it is essential that these tests meet the user requirements. WP1 is therefore also developing user requirement specifications in line with ongoing and published global efforts to determine Target Product Profiles for diagnostics addressing the antibiotic resistance challenge.<\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-3b8mw-b506a38e8d00a7f4906eea669cebc6be\">\n.flex_column.av-3b8mw-b506a38e8d00a7f4906eea669cebc6be{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-3b8mw-b506a38e8d00a7f4906eea669cebc6be av_one_fifth  avia-builder-el-6  el_after_av_one_full  el_before_av_one_fifth  first flex_column_div av-zero-column-padding  column-top-margin'     ><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-2lzlw-3d25ff9ce16d4f57844d3b5b4e0627c5\">\n.flex_column.av-2lzlw-3d25ff9ce16d4f57844d3b5b4e0627c5{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  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